Genetic Risk of age-related maculopathy
OBJECTIVE: To investigate to what extent age-related maculopathy (ARM) is genetically determined. DESIGN AND SETTING: Familial aggregation study based on probands derived from the population-based Rotterdam Study. PARTICIPANTS: First-degree relatives of 87 patients with late ARM, i.e., atrophic or neovascular macular degeneration, were compared with first-degree relatives of 135 control subjects without ARM. MAIN OUTCOME MEASURES: Presence and stage of ARM as diagnosed on fundus transparencies, odds ratio, lifetime risk, risk ratio, and population-attributable risk. RESULTS: Independent of oth... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 1998 |
| Schlagwörter: | Adult / Aged / 80 and over / Female / Genetics / Population / Human / Macular Degeneration/*epidemiology/*genetics / Male / Middle Aged / Netherlands/epidemiology / Nuclear Family / Odds Ratio / Ophthalmologic disease / Prevalence / Risk Factors / Support / Non-U.S. Gov't |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-27608344 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | http://repub.eur.nl/pub/5918 |
OBJECTIVE: To investigate to what extent age-related maculopathy (ARM) is genetically determined. DESIGN AND SETTING: Familial aggregation study based on probands derived from the population-based Rotterdam Study. PARTICIPANTS: First-degree relatives of 87 patients with late ARM, i.e., atrophic or neovascular macular degeneration, were compared with first-degree relatives of 135 control subjects without ARM. MAIN OUTCOME MEASURES: Presence and stage of ARM as diagnosed on fundus transparencies, odds ratio, lifetime risk, risk ratio, and population-attributable risk. RESULTS: Independent of other risk factors, the prevalence of early (odds ratio = 4.8, 95% confidence int