Cohort profile: the Netherlands Cohort Study on Acute HIV infection (NOVA), a prospective cohort study of people with acute or early HIV infection who immediately initiate HIV treatment

Purpose Initiation of combination antiretroviral therapy (cART) during acute or early HIV-infection (AEHI) limits the size of the viral reservoir and preserves immune function. This renders individuals who started cART during AEHI promising participants in HIV-cure trials. Therefore, we established a multicentre prospective cohort study in the Netherlands that enrols people with AEHI. In anticipation of future cure trials, we will longitudinally investigate the properties of the viral reservoir size and HIV-specific immune responses among cohort participants. Participants Participants immediat... Mehr ...

Verfasser: Dijkstra, Maartje
Prins, Henrieke
Prins, Jan M
Reiss, Peter
Boucher, Charles
Verbon, Annelies
Rokx, Casper
de Bree, Godelieve
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Reihe/Periodikum: BMJ Open ; volume 11, issue 11, page e048582 ; ISSN 2044-6055 2044-6055
Verlag/Hrsg.: BMJ
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27606911
Datenquelle: BASE; Originalkatalog
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Link(s) : http://dx.doi.org/10.1136/bmjopen-2020-048582