Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF) >= 5% and low-frequency variants (0.5 ; Peer reviewed
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2017 |
Verlag/Hrsg.: |
Nature Publishing Group
|
Schlagwörter: | GENOME-WIDE ASSOCIATION / GENOTYPE IMPUTATION / GENETIC ARCHITECTURE / SAMPLES / LOCI / METAANALYSIS / NETHERLANDS / HAPLOTYPES / THOUSANDS / EUROPEANS / 3111 Biomedicine / 1182 Biochemistry / cell and molecular biology |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27606441 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/10138/198889 |