Effects of the SGLT2 inhibitor dapagliflozin on proteinuria in non -diabetic patients with chronic kidney disease (DIAMOND):a randomised, double-blind, crossover trial
Background: SGLT2 inhibition decreases albuminuria and reduces the risk of kidney disease progression in patients with type 2 diabetes. These benefits are unlikely to be mediated by improvements in glycaemic control alone. Therefore, we aimed to examine the kidney effects of the SGLT2 inhibitor dapagliflozin in patients with proteinuric kidney disease without diabetes. Methods: DIAMOND was a randomised, double-blind, placebo-controlled crossover trial done at six hospitals in Canada, Malaysia, and the Netherlands. Eligible participants were adult patients (aged 18–75 years) with chronic kidney... Mehr ...
| Verfasser: |
Cherney, David Z I
Dekkers, Claire C J
Barbour, Sean J
Cattran, Daniel
Abdul Gafor, Abdul Halim
Greasley, Peter J
Laverman, Gozewijn D
Lim, Soo Kun
Di Tanna, Gian Luca
Reich, Heather N
Vervloet, Marc G
Wong, Muh Geot
Gansevoort, Ron T
Heerspink, Hiddo J L |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2020 |
| Reihe/Periodikum: |
DIAMOND investigators , Cherney , D Z I , Dekkers , C C J , Barbour , S J , Cattran , D , Abdul Gafor , A H , Greasley , P J , Laverman , G D , Lim , S K , Di Tanna , G L , Reich , H N , Vervloet , M G , Wong , M G , Gansevoort , R T & Heerspink , H J L 2020 , ' Effects of the SGLT2 inhibitor dapagliflozin on proteinuria in non -diabetic patients with chronic kidney disease (DIAMOND) : a randomised, double-blind, crossover trial ' , Lancet Diabetes & Endocrinology , vol. 8 , no. 7 , pp. 582-593 . https://doi.org/10.1016/S2213-8587(20)30162-5 |
| Schlagwörter: |
Adolescent
/ Adult
/ Aged
/ Benzhydryl Compounds/adverse effects
/ Biomarkers/analysis
/ Canada/epidemiology
/ Cross-Over Studies
/ Double-Blind Method
/ Female
/ Follow-Up Studies
/ Glomerular Filtration Rate
/ Glucosides/adverse effects
/ Humans
/ Incidence
/ Male
/ Middle Aged
/ Netherlands/epidemiology
/ Prognosis
/ Prospective Studies
/ Proteinuria/chemically induced
/ Renal Insufficiency
/ Chronic/drug therapy
/ Sodium-Glucose Transporter 2 Inhibitors/adverse effects
/ Young Adult |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27602032 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
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https://hdl.handle.net/11370/c8db5d31-0d30-475e-ba1a-014a48f49106 |
