Hypertension, antihypertensives and mutations in the Von Hippel-Lindau gene in renal cell carcinoma: results from the Netherlands Cohort Study
OBJECTIVES: Hypertension and/or antihypertensive medication are reported to be risk factors of renal cell carcinoma (RCC). We investigated whether these risk factors are associated with von Hippel-Lindau gene (VHL) mutations in RCC. METHODS: The Netherlands Cohort Study on Diet and Cancer (NLCS) started in 1986 (n = 120 852 men and women) and uses the case-cohort methodology. After 11.3 years of follow-up, 337 RCC cases and 4774 subcohort members were available for analysis. DNA was isolated from paraffin-embedded tumour tissue for VHL analysis. RESULTS: Cohort members who reported hypertensio... Mehr ...
| Verfasser: |
Schouten, L.J.
van Dijk, B.A.C.
Oosterwijk, E.
Hulsbergen van Kaa, C.A.
Kiemeney, L.A.
Goldbohm, R.A.
Schalken, J.A.
van den Brandt, P.A. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2005 |
| Reihe/Periodikum: |
Schouten , L J , van Dijk , B A C , Oosterwijk , E , Hulsbergen van Kaa , C A , Kiemeney , L A , Goldbohm , R A , Schalken , J A & van den Brandt , P A 2005 , ' Hypertension, antihypertensives and mutations in the Von Hippel-Lindau gene in renal cell carcinoma: results from the Netherlands Cohort Study ' , Journal of Hypertension , vol. 23 , no. 11 , pp. 1997-2004 . https://doi.org/10.1097/01.hjh.0000186023.74245.48 |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27597572 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/d39b6ced-3ef1-4adc-a7fc-3ecea1808063 |
