Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer
Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. The relationship between promoter methylation of genes involved in CRC carcinogenesis and folate and alcohol intake was investigated. Methylation of the APC-1A, p14(ARF), p16(INK4A), hMLH1, O(6)-MGMT, and RASSF1A promoters was studied using methylation-specific PCR in 122 sporadic C... Mehr ...
| Verfasser: |
van Engeland, M.
Weijenberg, M.P.
Roemen, G.M.J.M.
Brink, M.
de Bruine, A.P.
Goldbohm, R.A.
van den Brandt, P.A.
Baylin, S.B.
de Goeij, A.F.P.M.
Herman, J.G. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2003 |
| Reihe/Periodikum: |
van Engeland , M , Weijenberg , M P , Roemen , G M J M , Brink , M , de Bruine , A P , Goldbohm , R A , van den Brandt , P A , Baylin , S B , de Goeij , A F P M & Herman , J G 2003 , ' Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer ' , Cancer Research , vol. 63 , no. 12 , pp. 3133-3137 . < http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12810640&dopt=Abstract > |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27596698 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/47e5a605-f943-45f4-9576-c711bd26bbfd |
