Role of genotoxicity assays in the regulation of chemicals in The Netherlands: considerations and experiences
This paper discusses genotoxicity testing and data interpretation as applied in The Netherlands in the context of the regulation of chemicals. Guidelines were first formulated in 1981 and their use evolved in practice, on the basis of increasing experience at the national and international levels. The distinction between in vitro assays to detect intrinsic genotoxic properties and in vivo assays as a subsequent phase to show the realization of this potential in an intact organism has always been a cornerstone of the Dutch approach. Several critical aspects of the use of short-term genotoxicity... Mehr ...
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Dokumenttyp: | TEXT |
Erscheinungsdatum: | 1991 |
Verlag/Hrsg.: |
Oxford University Press
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Schlagwörter: | ORIGINAL PAPERS |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27586655 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://mutage.oxfordjournals.org/cgi/content/short/6/6/487 |