Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors.

Geographic variability in coagulation across populations and their determinants are poorly understood.To compare thrombin (TG) and plasmin (PG) generation parameters between healthy Tanzanian and Dutch individuals, and to study associations with inflammation and different genetic, host and environmental factors.TG and PG parameters were measured in 313 Tanzanians of African descent living in Tanzania and 392 Dutch of European descent living in the Netherlands and related to results of a dietary questionnaire, circulating inflammatory markers, genotyping, and plasma metabolomics.Tanzanians exhi... Mehr ...