Long-term comparative effectiveness of antihypertensive monotherapies in primary prevention of cardiovascular events: a population-based retrospective inception cohort study in the Netherlands

Objective To determine the long-term effectiveness of antihypertensive monotherapies in primary prevention of cardiovascular events.Design Retrospective inception cohort study covering a 25-year study period.Setting University Groningen IADB.nl pharmacy prescription database with data from 1996 to 2020.Participants Patients aged 18 years or older, free of any cardiovascular disease (CVD) drug therapies prior to initiation of a preventive antihypertensive monotherapy (ACE inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), beta-blockers (BBs), calcium channel blockers (CCBs) and thiazi... Mehr ...