Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
BackgroundBRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs).MethodsWe characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs an... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2016 |
Reihe/Periodikum: | Breast Cancer Research, vol 18, iss 1 |
Verlag/Hrsg.: |
eScholarship
University of California |
Schlagwörter: | Biomedical and Clinical Sciences / Clinical Sciences / Oncology and Carcinogenesis / Breast Cancer / Cancer / 2.1 Biological and endogenous factors / Aetiology / Adult / Aged / BRCA1 Protein / BRCA2 Protein / Breast Neoplasms / Male / Female / Genetic Predisposition to Disease / Humans / Middle Aged / Mutation / Neoplasm Staging / Polymorphism / Single Nucleotide / Male breast cancer / BRCA1/2 / Pathology / Histologic grade / Genotype-phenotype correlations / kConFab Investigators / Hereditary Breast and Ovarian Cancer Research Group Netherlands / EMBRACE / Oncology & Carcinogenesis |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-27570930 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://escholarship.org/uc/item/63r387vc |