To assess changes in infant vaccination coverage in Flanders since 1999, an EPI-survey was performed in 2005. The parents of 1354 children aged 18-24 months were interviewed at home and the vaccination documents were checked. Several factors possibly related to vaccination status were examined with parametric and non-parametric methods. The coverage rate of recommended vaccines, i.e. poliomyelitis, tetanus-diphtheria-pertussis, H. influenzae type b (Hib), hepatitis B, measles-mumps-rubella (MMR) and meningococcal C, reached at least 92.2%, which is a significant rise for MMR, hepatitis B and Hib since 1999. The vaccinating physician, the employment situation of the mother and the family income were significant predictive factors for having received all recommended vaccine doses (complete schedule), also when considering only doses that were according to minimal age and interval criteria (valid schedule). (c) 2007 Elsevier Ltd. All rights reserved.