BackgroundIn September 2010 HPV-vaccination for young girls was added to the vaccination programme of Flanders. Vaccines are made available free of charge to all vaccinators. All vaccinations with free vaccines should be registered in the vaccination registry. The availability of the new partially reimbursed 9-valent HPV-vaccine caused some concern the participation degree in the vaccination programme might decrease with a fall in vaccination coverage as a result (91% in 2016).MethodsTo evaluate the impact of the new situation on the vaccination coverage, we compared the number of ordered and delivered free HPV-vaccines for the vaccination programme from the last years. On the other hand we extracted registrations of all given HPV-vaccinations in the target groups to see to what extent 9-valent HPV-vaccines are registered and might compensate a possible decrease in amount of delivered vaccines in the vaccination programmeResultsIn the first trimester of the new school year, the number of ordered vaccines by all vaccinators had decreased with 3310 vaccines compared to the same period in 2016. Nevertheless, a total number of 2081 vaccinations with other brands of HPV-vaccines were registered, 1905 of which with 9-valent vaccines. Considering the non-obligation for registration of these other vaccinations, there might be some degree of under-registration.ConclusionsThe availability of a partially reimbursed 9-valent HPV-vaccine besides the organised vaccination programme (free of charge) has reduced the number of delivered vaccines for the programme. However, there is an increase in registered other HPV-vaccinations. Considering the amount of vaccines registered in the target group of girls, this situation doesnu2019t seem to alter vaccination coverage substantially, but needs a careful follow-up.