Harmonisation of factor VIII:C assay results: study within the framework of the Dutch project ‘Calibration 2000’

Summary In a Dutch project for harmonisation of factor VIII coagulant activity (FVIII:C) assays, the commutability of potential calibrators for FVIII:C was assessed by means of a ‘twin‐study design’, which is in essence a multi‐centre, split‐patient sample, between‐field‐methods protocol. Commutability was defined as the degree to which a material yielded the same numerical relationships between results of measurements by a given set of measurement procedures as those between the expectations of the relationships for the same procedures applied to those types of material for which the procedur... Mehr ...