The Dutch National e-Infrastructure for Research (DNI) was reorganised in 2013 in order to increase the integration between the infrastructure platforms offered. The SURF Cooperative was charged with leadership of this integrated ecosystem. Since then, there has been much progress and activity towards increased utility, ubiquity, and ease-of-use of the DNI. Significant effort has also been expended in the area of user support and outreach, national alignment between several data repositories, and innovation of the infrastructure. eScience research and engineering, best practices and policies regarding data stewardship and software sustainability have been addressed by the Netherlands eScience Center which is closely associated with the DNI. This paper will cover these topics, as well as outline the current challenges faced in improving the reach and quality of the infrastructure, as well the DNI’s position in the international e-infrastructure ecosystem. ; To appear in Proceedings of Science edition of the International Symposium on Grids and Clouds (ISGC) 2016 13-18 March 2016, Academia Sinica, Taipei, Taiwan