Improving the Dutch newborn screening for central congenital hypothyroidism by using 95% reference intervals for thyroxine-binding globulin
Introduction: Newborn screening (NBS) for congenital hypothyroidism (CH) in the Netherlands consists of thyroxine (T4), thyroid-stimulating hormone (TSH), and T4-binding globulin (TBG) measurements to detect thyroidal CH and central CH (CH-C). CH-C is detected by T4 or a calculated T4/ TBG ratio, which serves as an indirect measure of free T4. TSH and TBG are only measured in the lowest 20 and 5% of daily T4 values, respectively. A recent evaluation of the Dutch NBS for CH showed that the T4 and T4/TBG ratio contribute to the detection of CH-C but also lead to a low positive predictive value (... Mehr ...
Verfasser: |
Stroek, Kevin
Heijboer, Annemieke C.
van Veen-Sijne, Marja
Bosch, Annet M.
van der Ploeg, Catharina P. B.
Zwaveling-Soonawala, Nitash
de Jonge, Robert
van Trotsenburg, A. S. Paul
Boelen, Anita |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2021 |
Reihe/Periodikum: |
Stroek , K , Heijboer , A C , van Veen-Sijne , M , Bosch , A M , van der Ploeg , C P B , Zwaveling-Soonawala , N , de Jonge , R , van Trotsenburg , A S P & Boelen , A 2021 , ' Improving the Dutch newborn screening for central congenital hypothyroidism by using 95% reference intervals for thyroxine-binding globulin ' , EUROPEAN THYROID JOURNAL , vol. 10 , no. 3 , pp. 222-229 . https://doi.org/10.1159/000513516 |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27464961 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vumc.nl/en/publications/82818798-9e26-4f01-b957-d31f736f7892 |