Objective: In the Netherlands a nationwide guideline was introduced in 2016, which recommended routine Lynch syndrome screening (LSS) for all women with endometrial cancer (EC) <70 years of age. LSS consists of immunohistochemical (IHC) staining for loss of mismatch repair (MMR) protein expression, supplemented with MLH1 methylation analysis if indicated. Test results are evaluated by the treating gynaecologist, who refers eligible patients to a clinical geneticist. We evaluated the implementation of this guideline. Methods: From the nation-wide pathology database we selected all women diag... Mehr ...
| Verfasser: |
Tjalsma, Albert
Wagner, Anja
Dinjens, Winand
Graham, Patricia
Alcaa, LSM
de Groot, MER
Hamoen, KE
van Hof, AC
Hofhuis, W
Hofman, LN
Hoogduin, KJ
Kaijser, J
Makkus, ACF
Mol, SJJ
Plaisier, GM
Schelfhout, K
Smedts, HPM
Smit, R
Timmers, P
Vencken, P
Visschers, B
van der Wurff, AAM
van Doorn, Lena |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2021 |
| Reihe/Periodikum: |
Tjalsma , A , Wagner , A , Dinjens , W , Graham , P , Alcaa , LSM , de Groot , MER , Hamoen , KE , van Hof , AC , Hofhuis , W , Hofman , LN , Hoogduin , KJ , Kaijser , J , Makkus , ACF , Mol , SJJ , Plaisier , GM , Schelfhout , K , Smedts , HPM , Smit , R , Timmers , P , Vencken , P , Visschers , B , van der Wurff , AAM & van Doorn , L 2021 , ' Evaluation of a nationwide Dutch guideline to detect Lynch syndrome in patients with endometrial cancer ' , Gynecologic Oncology , vol. 160 , no. 3 , pp. 771-776 . https://doi.org/10.1016/j.ygyno.2020.12.028 |
| Schlagwörter: |
/dk/atira/pure/keywords/researchprograms/AFL001000/EMCOR01
/ name=EMC OR-01
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27460249 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://pure.eur.nl/en/publications/c548666e-7928-4982-b2a4-2ea6f4cec2bd |
