Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM?
Introduction: Studies suggest that the HIV-1 epidemic in the Netherlands may have become more virulent, leading to faster disease progression if untreated. Analysis of CD4 cell count decline before antiretroviral therapy (ART) initiation, a surrogate marker for disease progression, may be hampered by informative censoring as ART initiation is more likely with a steeper CD4 cell count decline. Methods: Development of CD4 cell count from 9 to 48 months after seroconversion was analyzed using a mixed-effects model and 2 models that jointly modeled CD4 cell counts and time to censoring event (star... Mehr ...
Verfasser: |
Gras, L
Geskus, RB
Jurriaans, S
den Bakker, Michael
van Sighem, A
Bezemer, D
Fraser, C
Prins, JM
Berkhout, B
de Wolf, F |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2013 |
Reihe/Periodikum: |
Gras , L , Geskus , RB , Jurriaans , S , den Bakker , M , van Sighem , A , Bezemer , D , Fraser , C , Prins , JM , Berkhout , B & de Wolf , F 2013 , ' Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM? ' , PLoS One (print) , vol. 8 , no. 5 . https://doi.org/10.1371/journal.pone.0064437 |
Schlagwörter: |
/dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM042701
/ name=EMC MM-04-27-01
/ /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM042804
/ name=EMC MM-04-28-04
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
unknown |
Permalink: |
https://search.fid-benelux.de/Record/base-27460179 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://pure.eur.nl/en/publications/b514aa97-9ccd-4742-8983-5e970f2c02d4 |