Locoregional control using highly conformal flank target volumes and volumetric-modulated arc therapy in pediatric renal tumors: Results from the Dutch national cohort

Background and purpose: In pediatric renal tumors, conventional two opposing photon beams have been used to cover the postoperative flank target volume for decades. This single center study describes the locoregional outcome using highly conformal flank target volumes adjusted for postoperative changes and intra-fraction motion combined with Volumetric-Modulated Arc Therapy (VMAT). Materials and methods: Between 01-2015 and 12-2019, 36/161 newly diagnosed patients with renal tumors underwent flank only irradiation (n = 30) or flank + whole lung irradiation (n = 6) using highly conformal target... Mehr ...

Verfasser: Mul, Joeri
van Grotel, Martine
Seravalli, Enrica
Bosman, Mirjam E.
van Tinteren, Harm
Roy, Prakriti
Dávila Fajardo, Raquel
Tytgat, Godelieve A.M.
Mavinkurve-Groothuis, Annelies M.C.
van de Ven, Cornelis P.
Wijnen, Marc H.W.A.
de Krijger, Ronald R.
Littooij, Annemieke S.
van den Heuvel-Eibrink, Marry M.
Janssens, Geert O.
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Schlagwörter: Flank irradiation / Highly conformal radiotherapy / Locoregional / Pediatric renal tumors / Tumor recurrences / VMAT / Radiotherapy Dosage / Prospective Studies / Neoplasm Recurrence / Local/radiotherapy / Humans / Kidney Neoplasms/radiotherapy / Child / Radiotherapy Planning / Computer-Assisted / Radiotherapy / Intensity-Modulated / Hematology / Oncology / Radiology Nuclear Medicine and imaging / Research Support / Non-U.S. Gov't / Journal Article
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27457731
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dspace.library.uu.nl/handle/1874/444058

Background and purpose: In pediatric renal tumors, conventional two opposing photon beams have been used to cover the postoperative flank target volume for decades. This single center study describes the locoregional outcome using highly conformal flank target volumes adjusted for postoperative changes and intra-fraction motion combined with Volumetric-Modulated Arc Therapy (VMAT). Materials and methods: Between 01-2015 and 12-2019, 36/161 newly diagnosed patients with renal tumors underwent flank only irradiation (n = 30) or flank + whole lung irradiation (n = 6) using highly conformal target volumes in line with the SIOP-RTSG consensus statement. VMAT consisted of full-arc 10MV photon beams optimized for constraints of the organs at risk. In case of locoregional relapses, image co-registration and dose reconstruction was performed. Each relapse was classified as either ‘infield’ (V95%relapse: ≥99.0%), ‘marginal’ (V95%relapse: 20.0–98.9%) or ‘outfield’ (V95%relapse: 0–19.9%). Results: At a median follow-up from diagnosis of 3.1 years (range:0.4–5.7), the estimated 2-year Locoregional Control Rate, Disease-Free Interval and Overall Survival were 94%, 91% and 94%, respectively. Locoregional relapse was observed in two patients. One patient had a combined tumor bed and regional recurrence, classified as infield (V95%relapse: 100%) and outfield (V95%relapse: 1.2%). The second patient had a regional relapse in the inferior vena cava classified as marginal recurrence (V95%relapse: 93%). Relapses would not have been adequately covered by conventional beams. Conclusions: This single center analysis provides encouraging evidence that excellent locoregional control can be obtained by using highly conformal flank target volumes with VMAT in pediatric renal tumors. The safety of this approach will be validated in a prospective multicenter study.