Digital search and visualisation technologies are combined into one methodological approach for structural public debate analysis of digital print and audiovisual media data archives called the “leveled approach”. This approach is conceptualised, developed and used for research into drug discourse in Dutch news media debates in this thesis, which consists of four studies into the reputation of drugs in post-war Dutch newspaper and radio debates. As each study contributes to digital method development in Digital Humanities and to the field of drug history, a section describing the digital search and analysis trajectory in the digitised media archive (distant reading) precedes each historical narrative (close reading). The four studies explore how the reputation of amphetamine (in chapter 1) and ecstasy (in chapters 2, 3 and 4) developed in a context of national drug regulation in the Netherlands. In this way, the hypothesis that Dutch drug regulation has been subject to an increasingly strong imperative to regulate in the post-war period is studied in the media domain. The findings of the four studies lead to three main conclusions about the development of the reputation of drugs in a context of discursive dynamics specific to the newspaper and radio debates. First, the discursive formation of drugs developed at a pace that was to some degree independent from developments in drug regulation: public unrest in the newspapers preceded amphetamine regulation, while ecstasy was commonly treated as a soft drug on the radio for many years after being classified as a hard drug. Second, the reputation of these drugs developed in a cross-media landscape in which international issues and local issues also had significant effects. Third, the discursive formation of ecstasy is best understood as multifaceted and contested, revolving around contrasting discursive strands defined by meaning constellations of 1) descriptions of the substance; 2) commonly connected actors; and 3) settings. In newspaper articles these discursive ...