Multiple Endocrine Neoplasia Type 1: The impact of screening: Results of the DutchMEN1 Study Group

The MEN1 syndrome is a hereditary disease characterized by the simultaneous occurrence of parathyroid, pituitary and duodenopancreatic neuroendocrine tumors. The prevalence of MEN1 is estimated at 3-4/100,000 with a high age-related penetrance of the three main manifestations. The clinical practice guideline for MEN1 recommends a strict screening protocol from an early age. The first part of this thesis elaborates on familial screening and the consequence of novel findings with regards to screening. The second part describes the impact of having the MEN1 syndrome and subsequent screening of th... Mehr ...