Long-term outcome of Multiple Endocrine Neoplasia type 1 related manifestations: Results from the DutchMEN1 Study Group.
Multiple Endocrine Neoplasia type 1 (MEN1) is a rare syndrome caused by mutations in the MEN1 gene on chromosome 11. It is characterized by the occurrence of primary hyperparathyroidism (pHPT), duodenopancreatic neuroendocrine tumours (NET), pituitary tumours, adrenal adenomas and NET of the stomach, bronchus and thymus. The research in this thesis focusses on the long-term outcome of MEN1 related manifestations. Since the discovery of the MEN1 gene in 1997, presymptomatic genetic testing became available. In the research described in chapter 3 we show that patients with a genetic diagnosis ha... Mehr ...
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Dokumenttyp: | Dissertation |
Erscheinungsdatum: | 2018 |
Verlag/Hrsg.: |
Utrecht University
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Schlagwörter: | MEN1 / NF-pNETs / pHPT / Natural course / genotype-phenotype correlation |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27456350 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/362800 |