Neurodevelopmental outcome at 5.5 years in Dutch preterm infants born at 24-26 weeks' gestational age:the EPI-DAF study

OBJECTIVE: After lowering the Dutch threshold for active treatment from 25 to 24 completed weeks' gestation, survival to discharge increased by 10% in extremely preterm live born infants. Now that this guideline has been implemented, an accurate description of neurodevelopmental outcome at school age is needed. DESIGN: Population-based cohort study. SETTING: All neonatal intensive care units in the Netherlands. PATIENTS: All infants born between 240/7 and 266/7 weeks' gestation who were 5.5 years' corrected age (CA) in 2018-2020 were included. MAIN OUTCOME MEASURES: Main outcome measure was ne... Mehr ...

Verfasser: van Beek, Pauline E.
Rijken, Monique
Broeders, Lisa
ter Horst, Hendrik J.
Koopman-Esseboom, Corine
de Kort, Ellen
Laarman, A.R.C.
Mulder-de Tollenaer, S.M.
Steiner, Katerina
Swarte, Renate M.C.
van Westering-Kroon, Elke
Oei, Guid
Leemhuis, Aleid G.
Andriessen, Peter
Dokumenttyp: Artikel
Erscheinungsdatum: 2024
Reihe/Periodikum: van Beek , P E , Rijken , M , Broeders , L , ter Horst , H J , Koopman-Esseboom , C , de Kort , E , Laarman , A R C , Mulder-de Tollenaer , S M , Steiner , K , Swarte , R M C , van Westering-Kroon , E , Oei , G , Leemhuis , A G & Andriessen , P 2024 , ' Neurodevelopmental outcome at 5.5 years in Dutch preterm infants born at 24-26 weeks' gestational age : the EPI-DAF study ' , Archives of Disease in Childhood : Fetal and Neonatal Edition , vol. 109 , no. 3 , pp. 272-278 . https://doi.org/10.1136/archdischild-2023-325732
Schlagwörter: epidemiology / neonatology / neurology / Infant / Premature / Diseases/epidemiology / Prospective Studies / Humans / Child / Preschool / Developmental Disabilities/epidemiology / Gestational Age / Pregnancy / Female / Extremely Premature / Newborn / Cohort Studies
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27449756
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.tue.nl/en/publications/52a9cdfd-7d0d-448d-8421-dc7372d9d900

OBJECTIVE: After lowering the Dutch threshold for active treatment from 25 to 24 completed weeks' gestation, survival to discharge increased by 10% in extremely preterm live born infants. Now that this guideline has been implemented, an accurate description of neurodevelopmental outcome at school age is needed. DESIGN: Population-based cohort study. SETTING: All neonatal intensive care units in the Netherlands. PATIENTS: All infants born between 240/7 and 266/7 weeks' gestation who were 5.5 years' corrected age (CA) in 2018-2020 were included. MAIN OUTCOME MEASURES: Main outcome measure was neurodevelopmental outcome at 5.5 years. Neurodevelopmental outcome was a composite outcome defined as none, mild or moderate-to-severe impairment (further defined as neurodevelopmental impairment (NDI)), using corrected cognitive score (Wechsler Preschool and Primary Scale of Intelligence Scale-III-NL), neurological examination and neurosensory function. Additionally, motor score (Movement Assessment Battery for Children-2-NL) was assessed. All assessments were done as part of the nationwide, standardised follow-up programme. RESULTS: In the 3-year period, a total of 632 infants survived to 5.5 years' CA. Data were available for 484 infants (77%). At 5.5 years' CA, most cognitive and motor (sub)scales were significantly lower compared with the normative mean. Overall, 46% had no impairment, 36% had mild impairment and 18% had NDI. NDI-free survival was 30%, 49% and 67% in live born children at 24, 25 and 26 weeks' gestation, respectively (p<0.001). CONCLUSIONS: After lowering the threshold for supporting active treatment from 25 to 24 completed weeks' gestation, a considerable proportion of the surviving extremely preterm children did not have any impairment at 5.5 years' CA.