Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response
Glucocorticoids form the backbone of paediatric acute lymphoblastic leukaemia (ALL) treatment. Many studies have been performed on steroid resistance; however, few studies have addressed the relationship between dose, concentration and clinical response. The aim of the present study was to evaluate the pharmacokinetics of prednisolone in the treatment of paediatric ALL and the correlation with clinical parameters. A total of 1028 bound and unbound prednisolone plasma concentrations were available from 124 children (aged 0-18 years) with newly diagnosed ALL enrolled in the Dutch Childhood Oncol... Mehr ...
Verfasser: |
Sassen, Sebastiaan D. T.
Mathot, Ron A. A.
Pieters, Rob
de Haas, Valerie
Kaspers, Gertjan J. L.
van den Bos, Cor
Tissing, Wim J. E.
te Loo, D. Maroeska W. W.
Bierings, Marc B.
van Der Sluis, Inge M.
Zwaan, C. Michel |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2021 |
Reihe/Periodikum: |
Sassen , S D T , Mathot , R A A , Pieters , R , de Haas , V , Kaspers , G J L , van den Bos , C , Tissing , W J E , te Loo , D M W W , Bierings , M B , van Der Sluis , I M & Zwaan , C M 2021 , ' Evaluation of the pharmacokinetics of prednisolone in paediatric patients with acute lymphoblastic leukaemia treated according to Dutch Childhood Oncology Group protocols and its relation to treatment response ' , British Journal of Haematology , vol. 194 , no. 2 , pp. 423-432 . https://doi.org/10.1111/bjh.17572 |
Schlagwörter: |
acute lymphoblastic leukaemia
/ dexamethasone
/ NONMEM
/ paediatrics
/ pharmacokinetics
/ pharmacodynamics
/ prednisolone
/ LIMITED SAMPLING STRATEGIES
/ GLUCOCORTICOID RESISTANCE
/ DOWN-SYNDROME
/ AIEOP-BFM
/ IN-VITRO
/ CHILDREN
/ ASPARAGINASE
/ BINDING |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27447323 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://hdl.handle.net/11370/e4b77d06-603d-41d0-8ea9-5a264f374f16 |