Sex-biased genetic regulation of inflammatory proteins in the Dutch population
Background: Significant differences in immune responses, prevalence or susceptibility of diseases and treatment responses have been described between males and females. Despite this, sex-differentiation analysis of the genetic architecture of inflammatory proteins is largely unexplored. We performed sex-stratified meta-analysis after protein quantitative trait loci (pQTL) mapping using inflammatory biomarkers profiled using targeted proteomics (Olink inflammatory panel) of two population-based cohorts of Europeans. Results: Even though, around 67% of the pQTLs demonstrated shared effect betwee... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2024 |
Reihe/Periodikum: | Boahen , C K , Abee , H , Ponce , I R , Joosten , L A B , Netea , M G & Kumar , V 2024 , ' Sex-biased genetic regulation of inflammatory proteins in the Dutch population ' , BMC Genomics , vol. 25 , 154 . https://doi.org/10.1186/s12864-024-10065-z |
Schlagwörter: | Biomarkers / GWAS / Inflammation / pQTL / Sex-stratified genetic analysis |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27447226 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://hdl.handle.net/11370/d89913b1-c392-40c3-aa7a-123749ca7647 |