Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 × 10-10) signals near the LCT and ABO genes were found to be associated with multiple microbial taxa and pathways and were replicated in two independent cohorts. The LCT locus associations seemed modulated by lactose intake, whereas tho... Mehr ...
Verfasser: |
Lopera-Maya, Esteban A
Kurilshikov, Alexander
van der Graaf, Adriaan
Hu, Shixian
Andreu-Sánchez, Sergio
Chen, Lianmin
Vila, Arnau Vich
Gacesa, Ranko
Sinha, Trishla
Collij, Valerie
Klaassen, Marjolein A Y
Bolte, Laura A
Brandao Gois, Milla F
Neerincx, Pieter B T
Swertz, Morris A
Harmsen, Hermie J M
Wijmenga, Cisca
Fu, Jingyuan
Weersma, Rinse K
Zhernakova, Alexandra
Sanna, Serena |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2022 |
Reihe/Periodikum: |
Lopera-Maya , E A , Kurilshikov , A , van der Graaf , A , Hu , S , Lifelines Cohort Study , Andreu-Sánchez , S , Chen , L , Vila , A V , Gacesa , R , Sinha , T , Collij , V , Klaassen , M A Y , Bolte , L A , Brandao Gois , M F , Neerincx , P B T , Swertz , M A , Harmsen , H J M , Wijmenga , C , Fu , J , Weersma , R K , Zhernakova , A & Sanna , S 2022 , ' Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project ' , Nature genetics , vol. 54 , pp. 143-151 . https://doi.org/10.1038/s41588-021-00992-y |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27447149 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://hdl.handle.net/11370/cf562bf4-3bae-4ec5-a732-e55c316ea37c |