Ruxolitinib in Myelofibrosis and Baseline Thrombocytopenia in Real Life:Results in Dutch Patients and Review of the Literature

Real-life data on the treatment of myelofibrosis patients with baseline thrombocytopenia with ruxolitinib are limited. We present the outcomes of thrombocytopenic Dutch patients treated within a compassionate-use program. Additionally, we performed a literature review. We conclude that treatment of patients with platelet counts of 50 to 100 3 10(9)/L with ruxolitinib is safe. Background: Ruxolitinib is an approved treatment for myelofibrosis patients, but data regarding patients with baseline thrombocytopenia are limited. The EXPAND study recently suggested tolerability of ruxolitinib, with a... Mehr ...