Low Urinary Potassium Excretion Is Associated with Higher Risk of All-Cause Mortality in Patients with Type 2 Diabetes:Results of the Dutch Diabetes and Lifestyle Cohort Twente (DIALECT)

Background: Low 24-h urinary potassium excretion, reflecting low potassium intake, is associated with premature mortality in the general population. Objectives: To determine whether urinary potassium excretion is associated with all-cause mortality in patients with type 2 diabetes. Methods: We performed a prospective cohort study in 654 patients with type 2 diabetes in the Diabetes and Lifestyle Cohort Twente (DIALECT). Sex-specific tertiles of 24-h urinary potassium excretion were analyzed in a multivariable Cox regression model with all-cause mortality. The outpatient program of the hospital... Mehr ...

Verfasser: Yeung, Stanley MH
Oosterwijk, Milou M.
Poelstra, Monique
Gant, Christina M.
Rotmans, Joris I.
Hoorn, Ewout J.
Vogt, Liffert
Navis, Gerjan
Bakker, Stephan JL
de Borst, Martin H.
Laverman, Gozewijn D.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: Yeung , S MH , Oosterwijk , M M , Poelstra , M , Gant , C M , Rotmans , J I , Hoorn , E J , Vogt , L , Navis , G , Bakker , S JL , de Borst , M H & Laverman , G D 2022 , ' Low Urinary Potassium Excretion Is Associated with Higher Risk of All-Cause Mortality in Patients with Type 2 Diabetes : Results of the Dutch Diabetes and Lifestyle Cohort Twente (DIALECT) ' , The Journal of Nutrition , vol. 152 , no. 12 , pp. 2856-2864 . https://doi.org/10.1093/jn/nxac215
Schlagwörter: 24-hour urinary potassium excretion / all-cause mortality / diet / food-frequency questionnaire / type 2 diabetes
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27446369
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/79c58906-5fcc-47d5-bd4c-51568d8f9904

Background: Low 24-h urinary potassium excretion, reflecting low potassium intake, is associated with premature mortality in the general population. Objectives: To determine whether urinary potassium excretion is associated with all-cause mortality in patients with type 2 diabetes. Methods: We performed a prospective cohort study in 654 patients with type 2 diabetes in the Diabetes and Lifestyle Cohort Twente (DIALECT). Sex-specific tertiles of 24-h urinary potassium excretion were analyzed in a multivariable Cox regression model with all-cause mortality. The outpatient program of the hospital uses a continuous surveillance system by the municipal registry of death to ensure up-to-date information on the patient's status (alive or deceased). FFQs were used to study associations between urinary potassium excretion and food products. Results: Urinary potassium excretion at baseline was 84 ± 25 mmol/d in males and 65 ± 22 mmol/d in females, corresponding to estimated potassium intakes of 4250 ± 1270 mg/d and 3300 ± 875 mg/d. During a median follow-up of 5.2 (IQR: 2.7−7.9] y, 96 participants died. In a fully adjusted model, patients in the lowest sex-specific tertile had a higher risk of all-cause mortality, compared with patients in the highest sex-specific tertile (HR: 2.09; 95% CI: 1.06, 4.10; P = 0.03). Patients in the lowest sex-specific tertile consumed fewer fruits and vegetables, dairy, coffee, and potato products compared with patients in the highest sex-specific tertile (all P < 0.05). Conclusions: Low potassium intake is associated with a higher risk of all-cause mortality in Dutch patients with type 2 diabetes. Intervention studies are needed to determine whether potassium supplementation improves longevity in patients with type 2 diabetes. This trial was registered in the Dutch Trial Register as NTR trial code 5855.