Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone t... Mehr ...

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Verfasser: Kilsdonk, Ellen
van Dulmen-den Broeder, Eline
van Leeuwen, Flora E.
van den Heuvel-Eibrink, Marry M.
Loonen, Jacqueline J.
van der Pal, Helena J.
Bresters, Dorine
Versluys, A. B.
Pieters, Rob
Hauptmann, Michael
Jaspers, Monique W.M.
Neggers, Sebastian J.C.
Raphael, Martine F.
Tissing, Wim J.E.
Kremer, Leontine C.M.
Ronckers, Cécile M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2022
Reihe/Periodikum: LATER Study Group , Kilsdonk , E , van Dulmen-den Broeder , E , van Leeuwen , F E , van den Heuvel-Eibrink , M M , Loonen , J J , van der Pal , H J , Bresters , D , Versluys , A B , Pieters , R , Hauptmann , M , Jaspers , M W M , Neggers , S J C , Raphael , M F , Tissing , W J E , Kremer , L C M & Ronckers , C M 2022 , ' Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort ' , Cancer investigation , vol. 40 , no. 5 , pp. 413-424 . https://doi.org/10.1080/07357907.2022.2034841
Schlagwörter: Childhood cancer survivors / late mortality
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27445669
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/2be05c7a-4b56-4f94-ae2d-a1b9670d1283

This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).