Dexamethasone for the Prevention of a Pain Flare After Palliative Radiation Therapy for Painful Bone Metastases:The Multicenter Double-Blind Placebo-Controlled 3-Armed Randomized Dutch DEXA Study
Purpose: After radiation therapy for painful bone metastases, up to 44% of patients report a pain flare (PF). Our study compared 2 dose schedules of dexamethasone versus placebo to prevent PF. Methods and Materials: This double-blind, randomized, placebo-controlled trial allocated patients with painful bone metastases from solid tumors randomly to receive 8 mg dexamethasone before radiation therapy followed by 3 daily doses (group A), 8 mg dexamethasone followed by 3 doses of placebo (group B), or 4 doses of placebo (group C). Patients reported worst pain scores, study medication side effects,... Mehr ...
Verfasser: |
van der Linden, Yvette M.
Westhoff, Paulien G.
Stellato, Rebecca K.
van Baardwijk, Angela
de Vries, Kim
Ong, Francisca
Wiggenraad, Ruud
Bakri, Bonnie
Wester, Gerda
de Pree, Ilse
van Veelen, Lieneke
Budiharto, Tom
Schippers, Maaike
Reyners, Anna K. L.
de Graeff, Alexander |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
van der Linden , Y M , Westhoff , P G , Stellato , R K , van Baardwijk , A , de Vries , K , Ong , F , Wiggenraad , R , Bakri , B , Wester , G , de Pree , I , van Veelen , L , Budiharto , T , Schippers , M , Reyners , A K L & de Graeff , A 2020 , ' Dexamethasone for the Prevention of a Pain Flare After Palliative Radiation Therapy for Painful Bone Metastases : The Multicenter Double-Blind Placebo-Controlled 3-Armed Randomized Dutch DEXA Study ' , International Journal of Radiation Oncology Biology Physics , vol. 108 , no. 3 , pp. 546-553 . https://doi.org/10.1016/j.ijrobp.2020.05.007 |
Schlagwörter: |
CANCER-PATIENTS
/ RADIOTHERAPY
/ PROPHYLAXIS
/ QUESTIONNAIRE |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27440594 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://cris.maastrichtuniversity.nl/en/publications/f87adc28-76b2-4466-a1cc-09aa66767e94 |