Survival of sentinel node biopsy versus observation in intermediate-thickness melanoma: A Dutch population-based study
Background The Multicenter Selective Lymphadenectomy Trial (MSLT-1) comparing survival after a sentinel lymph node biopsy (SLNB) versus nodal observation in melanoma patients did not show a significant benefit favoring SLNB. However, in subgroup analyses melanoma-specific survival among patients with nodal metastases seemed better.Aim To evaluate the association of performing a SLNB with overall survival in intermediate thickness melanoma patients in a Dutch population-based daily clinical setting.Methods Survival, excess mortality adjusted for age, gender, Breslow-thickness, ulceration, histo... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | Roumen , R M H , Schuurman , M S , Aarts , M J , Maaskant-Braat , A J G , Vreugdenhil , G & Louwman , W J 2021 , ' Survival of sentinel node biopsy versus observation in intermediate-thickness melanoma: A Dutch population-based study ' , PLOS ONE , vol. 16 , no. 5 , e0252021 . https://doi.org/10.1371/journal.pone.0252021 |
Schlagwörter: | CUTANEOUS MELANOMA / PROGNOSTIC-SIGNIFICANCE / STAGE-I / DISSECTION / MANAGEMENT / ASSOCIATION / MULTICENTER / METASTASIS |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27439915 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/59b34382-1b15-4c39-a681-339c5241d5c4 |
Background The Multicenter Selective Lymphadenectomy Trial (MSLT-1) comparing survival after a sentinel lymph node biopsy (SLNB) versus nodal observation in melanoma patients did not show a significant benefit favoring SLNB. However, in subgroup analyses melanoma-specific survival among patients with nodal metastases seemed better.Aim To evaluate the association of performing a SLNB with overall survival in intermediate thickness melanoma patients in a Dutch population-based daily clinical setting.Methods Survival, excess mortality adjusted for age, gender, Breslow-thickness, ulceration, histological subtype, location, co-morbidity and socioeconomic status were calculated in a population of 1,989 patients diagnosed with malignant cutaneous melanoma (1.2-3.5 mm) on the trunk or limb between 2000-2016 in ten hospitals in the South East area, The Netherlands.Results A SLNB was performed in 51% of the patients (n = 1008). Ten-year overall survival after SLNB was 75% (95%CI, 71%-78%) compared to 61% (95%CI 57%-64%) following observation. After adjustment for risk factors, a lower risk on death (HR = 0.80, 95%CI 0.66-0.96) was found after SLNB compared to observation only.Conclusions SLNB in patients with intermediate-thickness melanoma on trunk or limb resulted in a 14% absolute and significant 10-year survival difference compared to those without SLNB.