Gynecological Surveillance and Surgery Outcomes in Dutch Lynch Syndrome Carriers
Lynch syndrome (LS) is caused by pathogenic germline variants in DNA mismatch repair (MMR) genes, predisposing female carriers for endometrial cancer (EC) and ovarian cancer (OC). Since gynecological LS surveillance guidelines are based on little evidence, we assessed its outcomes. Data regarding gynecological tumors, surveillance, and (risk-reducing) surgery were collected from female LS carriers diagnosed in our center since 1993. Of 505 female carriers, 104 had a gynecological malignancy prior to genetic LS diagnosis. Of 264 carriers eligible for gynecological management, 164 carriers gave... Mehr ...
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Dokumenttyp: | Text |
Erscheinungsdatum: | 2021 |
Verlag/Hrsg.: |
Multidisciplinary Digital Publishing Institute
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Schlagwörter: | Lynch syndrome / gynecological surveillance / endometrial cancer / ovarian cancer / DNA mismatch repair / risk-reducing surgery / MLH1 / MSH2 / MSH6 / PMS2 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27415644 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.3390/cancers13030459 |