Plasma amyloid‐beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre‐symptomatic Dutch‐type hereditary CAA (D‐CAA) mutation‐carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre‐symptomatic members of a D‐ CAA pedigree were assembled and followed up 3–4 years later (NC = 8;MC = 9). Plasma Aβ1‐40 and Aβ1‐42 were cross‐sectionally and longitudin... Mehr ...
Verfasser: |
Chatterjee, Pratishtha
Tegg, Michelle
Pedrini, Steve
Fagan, Anne M.
Xiong, Chengjie
Singh, Abhay K.
Taddei, Kevin
Gardener, Samantha
Masters, Colin L.
Schofield, Peter R.
Multhaup, Gerhard
Benzinger, Tammie L. S.
Morris, John C.
Bateman, Randall J.
Greenberg, Steven M.
van Buchem, Mark A.
Stoops, Erik
Vanderstichele, Hugo
Teunissen, Charlotte E.
Hankey, Graeme J.
Wermer, Marieke J. H.
Sohrabi, Hamid R.
Martins, Ralph N. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2021 |
Reihe/Periodikum: |
Chatterjee , P , Tegg , M , Pedrini , S , Fagan , A M , Xiong , C , Singh , A K , Taddei , K , Gardener , S , Masters , C L , Schofield , P R , Multhaup , G , Benzinger , T L S , Morris , J C , Bateman , R J , Greenberg , S M , van Buchem , M A , Stoops , E , Vanderstichele , H , Teunissen , C E , Hankey , G J , Wermer , M J H , Sohrabi , H R , Martins , R N 2021 , ' Plasma amyloid‐beta levels in a pre‐symptomatic Dutch‐type hereditary cerebral amyloid angiopathy pedigree : a cross‐sectional and longitudinal investigation ' , International Journal of Molecular Sciences , vol. 22 , no. 6 , 2931 , pp. 1-12 . https://doi.org/10.3390/ijms22062931 |
Schlagwörter: |
Amyloid‐beta
/ Blood biomarkers
/ Cerebral amyloid angiopathy
/ Early diagnosis
/ Hereditary cerebral haemorrhage with amyloidosis—Dutch type
/ Plasma amyloid‐beta
/ Single molecule array platform |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27415323 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://researchers.mq.edu.au/en/publications/dce08bc8-ebbb-4950-a311-7f52b64a822e |