Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study

The interactions between environmental factors and the genetic and epigenetic changes that drive colon carcinogenesis are not clear. Dietary factors reported previously to be associated with colon cancer risk may well influence the occurrence of specific somatic alterations in colon tumors. To explore this idea, data from a Dutch population-based case-control study (184 cases, 259 controls) on sporadic colon cancer were used to assess associations between dietary factors and the occurrence of truncating mutations in the adenomatous polyposis coli ( APC ) gene in carcinomas. Single-strand confo... Mehr ...