This study aims to explain the relationship between Raja Ampat and the Tidore Sultanate beforethe era of Sultan Nuku. The paper discusses the causes of the conflict between Sultan Nuku and the Dutch Company in the XVIII-early nineteenth century. By research and discussion, it is clearly inform that before Nuku became tobe powerfull, the Tidore sultanate had contact with the area now known as Raja Ampat (then called Papua). Based on this relationship, when the VOC interfered in replacing the power holder to the throne of the Tidore sultanate, Sultan Nuku protested and moved out of Tidore island to Raja Ampat to form a war force from the area of influence of the Tidore sultanate. The strength of the troops that including the people of East Halmahera, the islands of Raja Ampat, and the island of Seram, were able to be mobilized to fight to reclaim the throne of the Tidore sultanate, which had previously been controlled by a leader appointed by the VOC as sultan as a measure of work, both in the Dutch bureaucracy and the indigenous bureaucracy.