v, 45 p. ; The Regions for Health Network (RHN), established in 1992, is a platform through which more than 30 regions and many associated partners in the WHO European Region work together to address and share experiences to improve population and individual health and well-being. The RHN’s annual meetings provide a forum for regions to come together, report on progress and plan future joint activities. The 27th annual meeting was hosted by the Flanders region in Belgium, and took place on 5–7 December 2022 in Brussels. On the first day, a joint high-level conference organized by RHN, the European Regional and Local Health Authorities and the European Committee of the Regions was held to discuss three important topics: digital health, cross-border cooperation and value-based health care. On 6 and 7 December, participants shared insights on regional health governance for better health and well-being, with a focus on the thematic issues mental health, behavioural insights, human resources for health, climate change, caring neighbourhoods and integrated care. Participants also discussed a joint roadmap for health and well-being for the RHN, including priority themes and activities for 2023–2026.