Abstract The Late Cretaceous and Cenozoic sedimentary record in the Campine Basin along the southern border of the North Sea Basin is analysed in terms of sequence stratigraphy. All available biostratigraphic, and in some cases, magnetostratigraphic data are used to constrain the sequence chronostratigraphy. The relative geographic extent of the strata is used as an indication of the relative sea level. Tectonic and eustatic components could be distinguished in several cases using regional geological information. Generally, sequences consist of transgressive and highstand systems tracts only and have flat, abrasion-type lower boundaries. Lowstand deposits are only identified as infill of erosional space, which generally implies marked tectonic uplift. Several eustatic and tectonic events can be correlated with similar events known elsewhere in the North Sea Basin. The time intervals spanned by the different sequences vary considerably, pointing out different control mechanisms.