Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

Abstract: We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

Verfasser: Xavier, Britto Basil
Lammens, Christine
Ruhal, R.
Kumar-Singh, Samir
Butaye, P.
Goossens, Herman
Malhotra, Surbhi
Dokumenttyp: Artikel
Erscheinungsdatum: 2016
Schlagwörter: Human medicine
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27377868
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/10067/1349490151162165141