Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts.

Journal Article; ; BACKGROUND Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight. METHODS We used data from two independent European cohorts: INMA (n = 376; Spain) and ENVIRONAGE (n = 550; Belgium). Relative placental mtDNA... Mehr ...

Verfasser: Clemente, Diana B P
Casas, Maribel
Vilahur, Nadia
Begiristain, Haizea
Bustamante, Mariona
Carsin, Anne-Elie
Fernández, Mariana F
Fierens, Frans
Gyselaers, Wilfried
Iñiguez, Carmen
Janssen, Bram G
Lefebvre, Wouter
Llop, Sabrina
Olea, Nicolás
Pedersen, Marie
Pieters, Nicky
Santa Marina, Loreto
Souto, Ana
Tardón, Adonina
Vanpoucke, Charlotte
Vrijheid, Martine
Sunyer, Jordi
Nawrot, Tim S
Dokumenttyp: research article
Erscheinungsdatum: 2016
Verlag/Hrsg.: National Institute of Environmental Health Sciences (NIEHS)
Schlagwörter: Contaminación del aire / Bélgica / Peso al nacer / ADN mitocondrial / Femenino / Desarrollo fetal / Retardo del crecimiento fetal / Genes mitocondriales / Modelos Lineales / Mitocondrias / Dióxido de nitrógeno / Placenta / Embarazo / España / Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Air Pollution / Medical Subject Headings::Geographicals::Geographic Locations::Europe::Belgium / Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Birth Weight / Medical Subject Headings::Chemicals and Drugs::Nucleic Acids / Nucleotides / and Nucleosides::Nucleic Acids::DNA::DNA / Circular::DNA / Mitochondrial / Medical Subject Headings::Check Tags::Female / Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Fetal Development / Medical Subject Headings::Diseases::Pathological Conditions / Signs and Symptoms::Pathologic Processes::Growth Disorders::Fetal Growth Retardation / Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes / Medical Subject Headings::Analytical / Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models / Statistical::Linear Models / Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria / Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Gases::Nitrogen Oxides::Nitrogen Dioxide / Medical Subject Headings::Anatomy::Embryonic Structures::Placenta / Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy / Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27375228
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://hdl.handle.net/10668/2555

Journal Article; ; BACKGROUND Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight. METHODS We used data from two independent European cohorts: INMA (n = 376; Spain) and ENVIRONAGE (n = 550; Belgium). Relative placental mtDNA content was determined as the ratio of two mitochondrial genes (MT-ND1 and MTF3212/R3319) to two control genes (RPLP0 and ACTB). Effect estimates for individual cohorts and the pooled data set were calculated using multiple linear regression and mixed models. We also performed a mediation analysis. RESULTS Pooled estimates indicated that a 10-μg/m3 increment in average NO2 exposure during pregnancy was associated with a 4.9% decrease in placental mtDNA content (95% CI: -9.3, -0.3%) and a 48-g decrease (95% CI: -87, -9 g) in birth weight. However, the association with birth weight was significant for INMA (-66 g; 95% CI: -111, -23 g) but not for ENVIRONAGE (-20 g; 95% CI: -101, 62 g). Placental mtDNA content was associated with significantly higher mean birth weight (pooled analysis, interquartile range increase: 140 g; 95% CI: 43, 237 g). Mediation analysis estimates, which were derived for the INMA cohort only, suggested that 10% (95% CI: 6.6, 13.0 g) of the association between prenatal NO2 and birth weight was mediated by changes in placental mtDNA content. CONCLUSION Our results suggest that mtDNA content can be one of the potential mediators of the association between prenatal air pollution exposure and birth weight. CITATION Clemente DB, Casas M, Vilahur N, Begiristain H, Bustamante M, Carsin AE, Fernández MF, Fierens F, Gyselaers W, Iñiguez C, Janssen BG, Lefebvre W, Llop S, Olea N, Pedersen M, Pieters N, Santa ...