Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population
Background: In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). Results: In 2027 participants randomly recruited from a Flemish population (51.0 % women; mean age 43.6 years), we genotyped six SNPs in MEOX2 and four in TCF15. Over 15.2 years (median), CHD, myocardial infarction, coronary revascularisation and ischaemic cardiomyopathy occurred in 106, 53, 78 and 22 participant... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2015 |
Verlag/Hrsg.: |
BioMed Central
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Schlagwörter: | Clinical genetic / Coronary heart disease / MEOX2 / Population science / TCF15 / Translational research / Adult / Basic Helix-Loop-Helix Transcription Factor / Belgium / Comorbidity / Coronary Artery Disease / Ethnic Group / Female / Genotype / Haplotype / Homeodomain Protein / Human / Incidence / Male / Middle Aged / Polymorphism / Single Nucleotide / Young Adult / Genetic Variation / Genetic / Genetics (clinical) / Settore MED/03 - Genetica Medica |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27352549 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2434/363000 |