Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
Introduction: It has been proposed that doses of amikacin of > 15 mg/kg should be used in conditions associated with an increased volume of distribution (V-d), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients. Methods: This was an open, prospective, multicenter study in four Belgian intensive care units (ICUs). All consecutive patients with a diagnosis of severe sepsis or septic shock, in whom amikacin treatment was indicated, were included in the study. Resu... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2010 |
Verlag/Hrsg.: |
BioMed Central Ltd
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Schlagwörter: | Shock / Septic / Severity of Illness Index / Prospective Studies / Middle Aged / Male / Humans / Female / Dose-Response Relationship / Drug / Belgium / Anti-Bacterial Agents / Amikacin / Aged |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27352415 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2078.1/33791 |