Non-native Berberis aquifolium is notoriously invasive in Belgian coastal dunes. With its strong clonal growth through suckers, this evergreen shrub outcompetes native species and affects dune succession. To prevent further secondary spread and mitigate its impact, there was an urgent need for knowledge on the effectiveness of control measures, both at the plant and habitat level. Here, we report on a first control experiment. Individual B. aquifolium clones were subjected to one of four treatments (manual uprooting, foliar herbicide application, stem cutting followed by herbicide or salt application), with regrowth being measured up to one year after treatment. Plants proved most susceptible to foliar herbicide application (5% glyphosate solution), resulting in 77% of the clones apparently killed. We discuss the limitations of our experiment and the potential for actual field application of the different treatments. We present some guidelines for future control that may become further refined as experience builds up.