Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib
Fusions of NTRK (neurotrophic tyrosine receptor kinase) genes with 5' partner genes can result in the expression of chimeric proteins that drive oncogenesis through ligand-independent kinase activation. Despite variable frequencies of NTRK fusions in different tumor types, the fact that they are common to a wide range of cancers raises the possibility of developing tumor-agnostic treatments specifically targeting NTRK fusion products, irrespective of tumor type. The first-generation Trk (tropomyosin receptor kinase) inhibitor, larotrectinib, was the first tumor-agnostic treatment of NTRK fusio... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | review |
Erscheinungsdatum: | 2022 |
Verlag/Hrsg.: |
ELSEVIER SCIENCE INC
|
Schlagwörter: | Larotrectinib / NTRK gene fusion / Trk inhibitor / Tumor-agnostic / Expert opinion / Oncogene proteins / Protein kinase inhibitors |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27305078 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/1942/36945 |