A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2).
Spongy degeneration with cerebellar ataxia (SDCA) is a genetically heterogeneous neurodegenerative disorder with autosomal recessive inheritance in Malinois dogs, one of the four varieties of the Belgian Shepherd breed. Using a combined linkage and homozygosity mapping approach we identified a ~10.6 Mb critical interval on chromosome 5 in a Malinois family with four puppies affected by cerebellar dysfunction. Visual inspection of the 10.6 Mb interval in whole genome sequencing data from one affected puppy revealed a 227 bp SINE insertion into the ATP1B2 gene encoding the β2 subunit of the Na(+... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2017 |
Verlag/Hrsg.: |
Genetics Society of America
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Schlagwörter: | 630 Agriculture / 570 Life sciences / biology / 590 Animals (Zoology) / 610 Medicine & health |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27303165 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://boris.unibe.ch/101833/1/2729.full.pdf |