Trends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic
We aimed to study epidemic trends and predictors for transmitted drug resistance (TDR) in our region, its clinical impact and its association with transmission clusters. We included 778 patients from the AIDS Reference Center in Leuven (Belgium) diagnosed from 1998 to 2012. Resistance testing was performed using population-based sequencing and TDR was estimated using the WHO-2009 surveillance list. Phylogenetic analysis was performed using maximum likelihood and Bayesian techniques. The cohort was predominantly Belgian (58.4%), men who have sex with men (MSM) (42.8%), and chronically infected... Mehr ...
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Dokumenttyp: | periodicalPart |
Erscheinungsdatum: | 2014 |
Verlag/Hrsg.: |
Robert Koch-Institut
Infektionskrankheiten / Erreger |
Schlagwörter: | Humans / Female / Male / Adult / Aged / Middle Aged / Risk Factors / Young Adult / Anti-HIV Agents/therapeutic use / HIV Infections/epidemiology / HIV Infections/virology / Prevalence / Genotype / Cluster Analysis / HIV-1/genetics / Retrospective Studies / HIV Infections/drug therapy / HIV-1/drug effects / Public Health Surveillance / Microbial Sensitivity Tests / HIV Infections/transmission / Drug Resistance Viral/genetics / Anti-HIV Agents/pharmacology / Belgium/epidemiology / Pregnancy / 610 Medizin / ddc:610 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27300729 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://edoc.rki.de/oa/articles/reKK9ywIyYlL/PDF/28Wr6usT6lPk.pdf |