The improvement of environmental impacts from production and consumption is an important sustainability target for Belgium, defined in federal and regional strategies for sustainable development. In order to monitor the implementation of sustainability targets a framework that can consistently link production and consumption and assess multiple environmental impacts such as climate change or resource use is needed. The most recognised method for the quantification of environmental impacts of product systems is life cycle assessment (LCA). Most LCAs focusing on production and consumption activities are carried out at national level. However, when regional differences in production and/or consumption structure exist, which is the case for Belgium, the use of more regionalised datasets and assessments seems more appropriate. This PhD thesis develops a multi-regional environmentally extended input-output model (EE-MRIOM) that can account for regional variation in production and consumption patterns and analyse environmental impacts of products from life cycle perspective. The model analysis three Belgian regions (Brussels, Flanders, Wallonia with a special focus on the latter) and their connections via trade flows with the rest of the world. The regional input-output tables (IOTs) of Belgium were linked to a global input-output database (EXIOBASE) and integrated into the LCA framework. The initial regional environmental data on major air emissions were extended by resource use and other emission data, so that a wide spectrum of potential environmental impacts can be analysed. The model represents all economic activities in 2003, 2007 and 2010 with a higher resolution in environmentally important sectors (e.g. energy, construction products, waste).The analysis of environmental impacts from production and consumption perspective confirms the relevance of the life cycle thinking approach, as, for example only 10 % of Walloon household environmental impacts are direct impacts and only 20 % of the Walloon ...