Background: Asthma is a chronic airway inflammatory disease, in which the excessive mucus adheres to the airway tube and causes narrowing of the respiration tube which is responsible for the difficulty in breathing. Around 235 million persons are affected with severe asthma worldwide. Purpose: The purpose of this study is to investigate and review the mechanisms of treatment strategies for asthma and the benefits or complications of nutrition supplements used in asthma, and the role of international agencies which stands for the treatment and management of asthma. Method: We search the randomized clinical trial, case reports, clinical studies, and preclinical studies with the use of search keys like asthma exacerbation, treatment strategies involve in asthma, Preclinical studies of asthma, supplement support or management of asthma, etc. we search the total 311 studies and based upon the inclusion criteria total 123 studies are included. Conclusion: According to the findings corticosteroids and Leukotrienes are mainly used for the treatment of early stages of asthma, for severe inflammation, the add-on therapy for corticosteroids with SABA and LABA may effective. Some biological compounds like Omalizumab, Reslizumab, and Benralizumab are used to treat asthma.