Introduction The costs of combination antiretroviral therapy (cART) consisting of separate, particularly generic, components are generally much lower than of a single tablet regimen (STR) including the same active ingredients. Our aim was to evaluate whether patients in care in the Netherlands would be willing to take separate component regimens (SCR) instead of an STR and to examine whether willingness was associated with particular patient characteristics. Materials and Methods Data from the HIV Monitoring Foundation of all adult HIV‐1‐infected patients in care taking cART>6 months were used to randomly select 1000 patients. As part of a questionnaire developed for a study assessing patient experience, patients were asked whether they were willing to take an SCR instead of an STR. Logistic regression was used to examine associations between age, gender, region of origin, mode of HIV transmission, socioeconomic status, duration of cART and answering “yes” to the question versus “maybe” or “no.” Variables with p<0.1 in the univariate analysis were entered in a multivariate model. Results Of the 300 patients who completed the questionnaire, 49% answered “yes,” 24% “maybe” and 27% “no” to the question whether they would be willing to use a SCR. Reasons for answering “no” included difficulties swallowing pills, convenience of STR (especially when travelling/at work), and concerns about side effects. Respondents who answered “maybe” often indicated that they preferred STRs, emphasized the importance of taking the pills once daily, and pointed out that efficacy/safety of an SCR should not be less. Having to pay for medication was reported as a reason to consider switching to an SCR. In the multivariate analysis, respondents who were born outside the Netherlands were less likely; and those with cART use ≥15 yrs were more likely to answer “yes” ( Table 1 ). Conclusions Half of the respondents were willing to take SCRs instead of an STR. The likelihood of accepting to switch to SCR seems less for migrants and for ...