2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio
Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are important biomarkers for disease development and progression. To gain insight into the genetic causes of variance in NLR and PLR in the general population, we conducted genome-wide association (GWA) analyses and estimated SNP heritability in a sample of 5901 related healthy Dutch individuals. GWA analyses identified a new genome-wide significant locus on the HBS1L-MYB intergenic region for PLR, which replicated in a sample of 2538 British twins. For platelet count, we replicated three known genome-wide significant... Mehr ...
Verfasser: |
Lin, Bochao Danae
Carnero-Montoro, Elena
Bell, Jordana T
Boomsma, Dorret I
de Geus, Eco J
Jansen, Rick
Kluft, Cornelis
Mangino, Massimo
Penninx, Brenda
Spector, Tim D
Willemsen, Gonneke
Hottenga, Jouke-Jan |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2017 |
Reihe/Periodikum: |
Lin , B D , Carnero-Montoro , E , Bell , J T , Boomsma , D I , de Geus , E J , Jansen , R , Kluft , C , Mangino , M , Penninx , B , Spector , T D , Willemsen , G & Hottenga , J-J 2017 , ' 2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio ' , Journal of human genetics , vol. 62 , no. 11 , pp. 979-988 . https://doi.org/10.1038/jhg.2017.76 |
Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27231632 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/c3a4c27e-8b37-48fb-b324-0be04b6bb8f1 |