The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances b-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 diabetes. Using the Metabochip, we identified three novel genetic loci with large effects (3040%) on GLP-1stimulated insulin secretion during hyperglycemic clamps in nondiabetic Caucasian individuals (TMEM114; CHST3 and CTRB1/2; n = 232; all P ≤8.8 × 10
| Verfasser: |
't Hart, L.M.
Fritsche, A.
Nijpels, G.
van Leeuwen, N.
Donnelly, L.A.
Dekker, J.M.
Alssema, M.J.
Fadista, J.
Carlotti, F.
Gjesing, A.P.
Palmer, C.N.A.
van Haeften, T.W.
Herzberg-Schäfer, S.A.
Bik-Simonis, A.M.C.
Houwing-Duistermaat, J.J.
Helmer, Q.
Deelen, J.
Guigas, B.
Hansen, T.
Machicao, F.
Willemsen, G.
Heine, R.J.
Kramer, M.H.H.
Holst, J.J.
de Koning, E.J.P.
Häring, H.U.
Pedersen, O.
Groop, L.
de Geus, E.J.C.
Slagboom, P.E.
Boomsma, D.I.
Eekhoff, E.M.W.
Pearson, E.R.
Diamant, M. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2013 |
| Reihe/Periodikum: |
't Hart , L M , Fritsche , A , Nijpels , G , van Leeuwen , N , Donnelly , L A , Dekker , J M , Alssema , M J , Fadista , J , Carlotti , F , Gjesing , A P , Palmer , C N A , van Haeften , T W , Herzberg-Schäfer , S A , Bik-Simonis , A M C , Houwing-Duistermaat , J J , Helmer , Q , Deelen , J , Guigas , B , Hansen , T , Machicao , F , Willemsen , G , Heine , R J , Kramer , M H H , Holst , J J , de Koning , E J P , Häring , H U , Pedersen , O , Groop , L , de Geus , E J C , Slagboom , P E , Boomsma , D I , Eekhoff , E M W , Pearson , E R & Diamant , M 2013 , ' The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway ' , Diabetes , vol. 62 , no. 9 , pp. 3275-3281 . https://doi.org/10.2337/db13-0227 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27231434 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/99cef3fb-c957-476a-9806-d1a8f80c2355 |
