Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We... Mehr ...
Verfasser: |
Coleman, Jonathan R I
Breen, Gerome
Abdellaoui, A.
Dolan, C.V.
Hottenga, Jouke Jan
Mbarek, Hamdi
Middeldorp, C.M.
Nivard, Michel G.
Willemsen, Gonneke
Boomsma, D.I.
de Geus, Eco J.C.
Beekman, A.T.F.
Jansen, Rick
Milaneschi, Yuri
Smit, Johannes H.
W J H Penninx, Brenda
Posthuma, Danielle |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
Coleman , J R I , Breen , G , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium , Abdellaoui , A , Dolan , C V , Hottenga , J J , Mbarek , H , Middeldorp , C M , Nivard , M G , Willemsen , G , Boomsma , D I , de Geus , E J C , Beekman , A T F , Jansen , R , Milaneschi , Y , Smit , J H , W J H Penninx , B & Posthuma , D 2020 , ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ' , Molecular Psychiatry , vol. 25 , no. 7 , pp. 1430-1446 . https://doi.org/10.1038/s41380-019-0546-6 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27231410 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/9376c309-535a-406a-9d36-b41ed712d9b5 |